Four species of rabbits (New Zealand, New ZeaLand X Balady, Balady X New Zealand and BalaDy). Five adult and healthy female rabbits from each species were chosen to estimate the levels of Total proteins, triacylglycerols, lipoproteins (LDL (Low Density Lipoproteins), HDL (High Density Lipoproteins) and VLDL (Very Low Density Lipoproteins)}, and cholesterol. Since, the present Study was one of the scientific plane of the Animal Reproduction Research Institute (ARRI), AlAhram, Giza, Egypt, so, all the rabbits were Raised under the balanced levels of nutrition at the Experimental farm of the institute. Serum samples Were collected from all the rabbits before pregnancy (day 0), during pregnancy (days 7, 14, 21, And 28) and 2 days after parturition (day 32). The Results revealed that there was a significant decrease in the total proteins level from the 14th day And during the day 21 of pregnancy, then a significant increase during the 28th day of pregnancy. The level of total proteins returned normal two Days after parturition. The behaviour of Triacylglycerols level was the same as total proteins but in the opposite direction. The level of lipoproteins And cholesterol were significant decreased from The 14th to the 28th day of pregnancy, then returns to normal two days after parturition. In general the figures of all the parameters, in this study. Were significantly higher in the New Zealand pure (NP) species followed by New Zealand X Balady (NC) then Balady X New Zealand (BC) species. The lowest parameters were noticed in the Balady Pure (BP) species.