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369256

EFFECT OF THE ANTIPARASITIC DRUG “CLOSANTEL” ON FETAL DEVELOPMENT AND SOME BIOCHEMICAL PARAMETERS IN RABBITS

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Pharmacology

Abstract

The teratogenic effect of closantel subcutaneously injected in doses of 5 and 10 mg / kg. b. wt. during the period of organogenesis was studied in rabbits. Moreover its effect on some serum bio- chemical constituents was studied. Closantel de- creased significantly fetal body weight and percentage of living foetuses. Dilatation of lateral ventricles of the brain, pericarditis, intrathoracic haemorrhage, hypoplasia of the lung, dilatation of renal pelvis, spinal bifida incomplete ossification of skull bones and absence of some sternbrae and phalanges were reported. Closantel increased significantly the activities of Aspartate aminotransferase (AST), Alanine ami- notransferase (ALT) and Alkaline phosphatase (ALP). It also increased the concentration of serum total bilirubin, urea and creatinine but de- creased the level of total protein.

DOI

10.21608/vmjg.2002.369256

Authors

First Name

AMANYE

Last Name

YOUSSEF

MiddleName

-

Affiliation

Animal Health Research Institute, Dokki, Giza.

Email

-

City

-

Orcid

-

Volume

50

Article Issue

2

Related Issue

49347

Issue Date

2002-04-01

Receive Date

2024-07-25

Publish Date

2002-04-01

Page Start

299

Page End

310

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 50_Issue 2_Pages 299-310.pdf

PDF . 3.8MB

Link

https://vmjg.journals.ekb.eg/article_369256.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=369256

Order

369,256

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

EFFECT OF THE ANTIPARASITIC DRUG “CLOSANTEL” ON FETAL DEVELOPMENT AND SOME BIOCHEMICAL PARAMETERS IN RABBITS

Details

Type

Article

Created At

23 Dec 2024