Two types of non-specific immunostimulant, fowl pox vaccine and dextran sulphate, were used to study the cellular and humoral immune response in chickens. The chickens were vaccinated with live P. multocida vaccine and live infectious bronchitis (IB) vaccine. The results proved that such materials enhanced the immune response either on the cellular or humoral levels. Fowl pox vaccine was more effective than dextran sulphate and both treated chicken groups gave significant difference in the immune response than chicken groups receive only either live P. multocida or infectious bronchitis (IB) vaccines.