The present study was conducted to evaluate the protective effects of Hydrated Sodium Calcium Aluminosilicate (HSCAS) and Egyptian Montmorillonite (EM) against PCBs-induced pathological and cytogenitical changes in talipia fish. Sixty male Nile tilapia fishes were divided into six treatment groups and treated orally with HSCAS or EM with or without PCBs (1.6 ug/kg b.w) for six weeks (three times/week). Treatment with PCBs alone resulted in adverse pathological lesions in kidney, liver and spleen. PCBs increased total structural and numerical chromosomal aberrations in the kidneys, increased micronucli erythrocytes and the concentration of DNA in liver tissues. Addition of HSCAS or EM resulted in a significant improvement in the histological lesions but with an evidence of renal calculi formation. Both sorbents materials succeeded in the decrease of the genotoxicity of somatic cells (79% and 67.9% for HSCAS and EM respectively), and inhibited micronulei erthrocytes (83.1% and 77.2% for HSCAS and EM respectively), where as, the inhibition of DNA concentration in liver tissue reached 58.2% and 56% for HSCAAS and EM respectively. It could be concluded that both HSCAS and EM had protective effects against PCBs toxicity. The proposed mechanism for such protection may be that these sorbent materials tightly bind and immobilize PCBs in the gastrointestinal tract resulting in the reduction of the toxin bioaviliability.