An epidemiological survey to screen the occurrence of brucellosis and toxoplasmosis in sheep, goats and humans was carried out. Six hundreds and twenty-five animals serum samples were collected from 375 sheep (155 aborted and 220 apparently healthy) and 250 goats (105 aborted and 145 apparently healthy). Beside 9 aborted foeti (5 from sheep and 4 from goats) were subjected for bacteriological examination. In addition, 125 human serum samples were taken from patients with fever (25), previously aborted women (25), shep-herds (35) and hospitalized patients (40). The serum samples were serologically examined for the presence of specific Brucella antibodies by Rose bengal plate test (RBPT), Buffered acidified plate antigen test (BAPAT) and tube agglutination test (TAT) and for the detection of Toxoplasma anti- bodies by latex agglutination test (LAT) and indirect haemagglutination test (IHAT). The results showed that the percentages of seropositive for brucellosis in sheep by RBPT, BAPAT and TAT were 10.1, 8.5 and 8% respectively, while their respective percentages in goat sera were 8, 6.8 and 6%. The overall percentages of Brucella seto-positive in aborted sheep and goat sera as estimated by RBPT, BAPAT and TAT (13.5, 11.9 and 11.2%) were higher than in apparently healthy animals (6.3, 4.9 and 4.4%). On the other hand, the seroprevalence of human brucellosis was 4.8, 4 and 3.2% as estimated by RBPT, BAPAT and TAT, respectively. Patients with fever showed 8%, while shepherds showed 5.7% Brucella sero- positive by TAT. Three isolates of Brucella melitensis biovar 3 were isolated from aborted foeti of sheep (two) and goats (one).Concerning the occurrence of Toxoplasma anti- bodies, the percentages of seropositive detected by LAT and IHAT were 24 & 22.1% in sheep and 21.2 & 19.2% in goats, respectively, while, the percentages in aborted sheep and goats (30.8 and 28.5%) were higher than in apparently healthy (17.3 & 15.6%).Regarding human, the percentages of Toxoplasma seropositive by LAT and IHAT were 18.4 and 16%, respectively. Moreover, the high percentage was detected in previously aborted women (36 and 32% by LAT and IHAT, respectively).It is concluded that brucellosis and toxoplasmosis are zoonotic disease wide-spread among the examined sheep and goat herds. This indicates that the potential role of these animals for dissemination and spread of such zoonoses in the examined areas. The zoonotic importance and the preventive measures necessary for combating brucellosis and toxoplasmosis in sheep, goats and humans were discussed.