Eight Haemorrhagic septicaemia (HS) vaccine formulations were evaluated to study their ability to elicit an early protective immunity in mice and calves. All HS vaccine formulations failed to protect mice against challenge with Pasteurella multocida virulent strain at 7th day post vaccination. Montanide ISA 25 vaccine was the best vaccine that could protect mice at 10th day post- immunization. Aluminum hydroxide gel and Saponin vaccine was the second vaccine that could protect mice at 15th day post-immunization. However, the other six formulations could protect mice between 21 and 35 day post-vaccination. The results of passive mouse protection test were in parallel with those of active mouse protection test.