The present investigation was carried on 35 Osemian sheep (3years old) in Borg El-Arab, Alexandria province, Egypt. Coenurosis syndrome was observed in 15 of them and was confirmed by finding Coenurus cerebralis cysts in the brains of two slaughtered sheep. The observed clinical signs were anorexia, the animal holds its head to one side and turns in circles. Erythrogram picture of sheep showing coenurosis syndrome revealed significant decrease in haemoglobin, RBCs count, packed cell volume and mean corpuscular haemoglobin concentration together with a significant increase in the mean corpuscular volume. Serum biochemical analysis revealed significant decrease in total proteins, albumin and A/G ratio together with slight increased serum globulins. Serum enzyme activities of the aspartate amino- transferase (AST) and creatine phosphokinase (C.P.K.) were significantly increased. Serum lipogram values of affected sheep showed signifcant increase of total lipids, total cholesterol, triacylglycerol, high density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoproteins (VLDL), free fatty acids and phospho- lipids. Vitamins "A" and "E" were significantly decreased in sheep showing coenurosis syndrome.It was concluded that coenurosis is a chronic depeletating disease that affects the general health condition and productivity of infected sheep.