The present work was conducted to study the possible protective role of Capparis spinosa leaves and their efficacy against hematological and histological alterations resulted in an animal model intoxicated with trichloroacetic acid (TCA). Hundred male mice 20-26 gm were divided into 5 groups; control group, group II treated orally with honey (40 mg/kg body weight for 3 weeks), group Ⅲ treated orally with a mixture of Capparis spinosa leaves powder and honey(40 mg/kg for 3 weeks), group IV treated with TCA in drinking water (500mg/kg for 3 and 6 weeks, then left for 3 weeks for recovery) and group V (Regeneration group) treated with TCA for 6 weeks then treated with a mixture of Capparis and honey (40 mg/kg for 3 weeks). Marked disturbance in the hematological parameters was demonstrated in mice treated with TCA for 3 and 6 weeks. Mice treated with TCA then with a mixture of Capparis spinosa leaves powder and honey showed an improvement in total leukocytic count and percentage of lymphocytes comparing to TCA treated group. Also, significant improvement in the platelets count was demonstrated. Histological examination of spleen sections of mice treated with TCA revealed obvious pathological findings including disorganization of lymphoid follicles, hyperplasia in white pulp, depletion of lymphocytes in red pulp with sub capsular edema, some necrotic cells in white and red pulp, increasing megakaryocytes, haemosiderosis and fibrosis in red pulp and in some lymphoid follicles. Administration of a mixture of Capparis spinosa leaves powder and honey lessened most of the pathological lesions in mice intoxicated with TCA.