Dromedary male camel displays unique sexual behavior and secretion of poll gland during breeding season. This study aimed to determine the effect of season on metabolism of androgens and the role played by the poll gland there on. Blood and tissues from testes, poll gland and liver were collected from camels during breeding and non-breeding seasons to estimate steroid concentrations testosterone (T), 5α- dihydrotestosterone (DHT) and estradiol (E2) and enzyme activity. Appreciable the activity of enzymes were found in testes and poll gland of rutting camels. Activity of α-reductase was equivalent in testes of rutting and non- rutting camels. However, it was significantly higher in poll gland of rutting tan in non rutting camels. The activity of the enzyme in rutting camels was significantly higher in poll gland than in testes. Aromatase activity was significantly greater in testes and poll gland of breeding males as compared to non- breeding ones. The liver of both breeding and non-breeding camels has low level of enzyme activity. The peripheral serum concentrations testosterone 5α- dihydrotestosterone (DHT) and estradiol-17β (E2) were significantly higher in breeding compared to non- breeding camels. The Results obtained indicate that breeding season leads to activation of poll gland with increasing the two pathways; α-reductase and aromatase activities and excessive DHT and E2 production in the camel.