Aqueous extract from leaves of sage (Salvia officinalis) was examined for its probable antiviral effect against Peste des Petits Ruminants attenuated virus (PPRV) using VERO cells. The cytotoxicity studies revealed that all the used dilutions of the aqueous extract of sage leaves were non-toxic to VERO cells. Incubation of the virus with the aqueous sage extract at concentration of 310.9 µg/ml for 4 hours at 37°C showed complete reduction in the virus titer. Intracellular treatment of the VERO cells before infection with the PPR virus with different concentrations of the aqueous sage leaves extract revealed only one log reduction in the virus titer compared to the virus control used. However, the antiviral effect of the aqueous sage leaves extract for the virus-infected VERO cells showed complete reduction in the virus titer at concentration of 310.9 µg/ml while at concentration of 77.72 µg/ml there was only one log reduction of the virus titer compared to the virus control used. Aqueous sage leaves extract is recommended to be used safely during outbreaks of PPR virus in sheep and goats after studying its antiviral effect in sheep and goats, safety and side effects.