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368251

Teratogenic effects of ciprofloxacin and pefloxacin in pregnant rats

Article

Last updated: 03 Jan 2025

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Tags

Pharmacology

Abstract

  The adverse effects of ciprofloxacin and pefloxacin on rat fetuses following oral administration to the pregnant rats were studied. Ciprofloxacin and pefloxacin were given daily to pregnant rats at two (therapeutic and double therapeutic) dosage levels during the period of organogenesis (from the 6thto the 15th day of gestation). Oral administration of ciprofloxacin at 4.5 and 9 mg/100 g.b.wt.to pregnant rats induced fetal resorption, death and growth retardation. Visceral examination of live fetuses showed microcephaly, hypoplasia of the heart and lungs and dilatation of renal pelvis.  Skeletal examination revealed incomplete ossification of skull bones and absence of some coccygeal. vertebrae. Pefloxacin at 7.2 6 mg/100 g. b. wt. decreased the number of live fetuses and caused microcephaly, hypoplasia of the heart and lungs, dilatation of the renal pelvis. It also induced incomplete ossification of skull bones and absence of sternbrae and phalanges of forelimbs. A great attention should be considered during the clinical use of ciprofloxacin and pefloxacin in pregnant women and animals to avoid their teratogenic effects.

DOI

10.21608/vmjg.2011.368251

Keywords

ciprofloxacin, Pefloxacin, Pregnancy, fetus, teratogenicity

Authors

First Name

Shalaby

Last Name

A

MiddleName

-

Affiliation

Pharmacology and Toxicology and Forensic Medicine Departments

Email

-

City

-

Orcid

-

First Name

El-Gendi

Last Name

Y

MiddleName

-

Affiliation

Pharmacology and Toxicology and Forensic Medicine Departments

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

S

MiddleName

-

Affiliation

Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Email

-

City

-

Orcid

-

Volume

59

Article Issue

3

Related Issue

49193

Issue Date

2011-07-01

Receive Date

2024-07-20

Publish Date

2011-07-01

Page Start

267

Page End

287

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 59_Issue 3_Pages 267-287.pdf

PDF . 5.6MB

Link

https://vmjg.journals.ekb.eg/article_368251.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=368251

Order

368,251

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Teratogenic effects of ciprofloxacin and pefloxacin in pregnant rats

Details

Type

Article

Created At

23 Dec 2024