Beta
ManageSearchChatDiscover
368250

Silent Effects of an Antiperspirant Containing Aluminum Chlorohydrate on Cytogenetic, Immunological and Histomorphological Profiles in Rats

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Physiology/endocrinology

Abstract

Twenty male rats were equally subdivided into control rats subjected to cutaneous rubbing of 1ml of distilled water daily on their shaved belly, and treated rats subjected to repeated cutaneous rubbing of 1 ml of an antiperspirant 24 deodorant on their shaved belly, daily for 50 consecutive days. Blood samples were withdrawn from each rat at the end of exposure periods and equal aliquots of heparinized blood samples were prepared: the first was used for total and differential leukocytic count and pahgocytic activity assay, while plasma of the second aliquot was utilized for screening concentrations of plasma total protein, albumin and globulin. Rats were then sacrificed, 2 hours after colchicine injection (i.p.), and their femoral bone marrows were flushed out for the preparation of metaphase plates and cytogenetic analysis of bone marrow chromosomes. The obtained data revealed a significant increase in the frequencies of aberrant cells and different types of chromosomal aberrations in the bone marrow cells of treated rats. Blood neutrophil phagocytic activities, plasma total protein and globulin were distinctly decreased and moderate histopathological and histomorphometric alterations of belly skin of the treated rats were observed. The study throws the light on the dangerous cumulative effects of this antiperspirant on cytogenetic, immunological and histomorphological profiles in Rats.

DOI

10.21608/vmjg.2011.368250

Keywords

Antiperspirant, aluminum chlorohydrate, Rats, Cytogenetic Analysis, Phagocytic activity, Histopathological, histomorphometric alterations

Authors

First Name

Abdel-Rahman

Last Name

A

MiddleName

-

Affiliation

Department of Physiology Faculty of Veterinary Medicine, Menoufiya University, Sadat City Branch, Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Assayed

Last Name

E

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology. Faculty of Veterinary Medicine, Menoufiya University, Sadat City Branch, Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Al Kafafy

Last Name

E

MiddleName

-

Affiliation

Department of Cytology and Histology Faculty of Veterinary Medicine, Menoufiya University, Sadat City Branch, Sadat City, Egypt

Email

-

City

-

Orcid

-

Volume

59

Article Issue

3

Related Issue

49193

Issue Date

2011-07-01

Receive Date

2024-07-20

Publish Date

2011-07-01

Page Start

247

Page End

266

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 59_Issue 3_Pages 247-266.pdf

PDF . 8.9MB

Link

https://vmjg.journals.ekb.eg/article_368250.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=368250

Order

368,250

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Silent Effects of an Antiperspirant Containing Aluminum Chlorohydrate on Cytogenetic, Immunological and Histomorphological Profiles in Rats

Details

Type

Article

Created At

23 Dec 2024