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368249

Evaluation of clinical and laboratory variables as diagnostic indicators of phenylbutazone toxicity in Egyptian draft horses

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Last updated: 03 Jan 2025

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Abstract

 To the best of the author's knowledge, this is the first report describing the diagnostic significance of clinical as well as various biochemical variables to predict the clinical outcome of phenylbutazone (PBZ) toxicity in Egyptian draft horses. Horses with PBZ toxicity were tentatively diagnosed based on competent case history and physical examination findings as well and post- mortem findings in non-survived cases. According to the clinical outcome, diseased horses were categorized into survivors (n= 21) and non-survivors (n=17). Clinically, there was a significant association between non-survivors and anorexia (p < 0.01), stasis of intestinal motility (p<0.01), melena (p < 0. 01), and diarrhoea (p < 0.001). Biochemically, malondialdehyde (MDA), nitric oxide (NO), aspartate amino transferase (AST), gamma glutamyl transferase (GGT), sorbitol dehydrogenase (SD), total bilirubin, urea and creatinine showed a significant increase (p<0.05) in non-survivors compared to survivors; meanwhile, superoxide dismutase activities (SOD), total plasma protein and albumin levels were significantly decreased (p<0.05). To predict the clinical outcome of PBZ toxicity in examined horses, receiver operating characteristic curve (ROC) was applied for all tested biochemical variables. Analysis of ROC curve showed high sensitivity and specificity of total leucocytic count (TLC), neutrophils, band cells as well as blood urea, creatinine, total plasma protein, AST, MDA, NO, SOD and vitamin C (Vit. C) levels. It could be concluded that clinical and biochemical investigations could provide valuable diagnostic information about the adverse effects of PBZ in draft horses. Our findings also suggest that estimation of these biochemical variables might help predict the outcomes of PBZ toxicity in Egyptian draft horses. 

DOI

10.21608/vmjg.2011.368249

Keywords

Phenylbutazone toxicity, Clinical, laboratory, Horses, Diagnosis

Authors

First Name

El-Ashker

Last Name

R

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Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Egypt

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First Name

El-Khodery

Last Name

A

MiddleName

-

Affiliation

Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Egypt

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City

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Orcid

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First Name

El-Boshy

Last Name

E

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Egypt

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City

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Orcid

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First Name

Nadia

Last Name

Metwally

MiddleName

-

Affiliation

Department of Medicinal chemistry, National Research Centre, Dokki, Giza, Egypt

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Orcid

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Volume

59

Article Issue

3

Related Issue

49193

Issue Date

2011-07-01

Receive Date

2024-07-20

Publish Date

2011-07-01

Page Start

235

Page End

246

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 59_Issue 3_Pages 235-246.pdf

PDF . 5.2MB

Link

https://vmjg.journals.ekb.eg/article_368249.html

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https://vmjg.journals.ekb.eg/service?article_code=368249

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368,249

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Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Evaluation of clinical and laboratory variables as diagnostic indicators of phenylbutazone toxicity in Egyptian draft horses

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Article

Created At

23 Dec 2024