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368231

Preparation and Evaluation of a Combined Inactivated Oil Emulsion Vaccine against Newcastle and Chicken Necrotic Enteritis Diseases

Article

Last updated: 03 Jan 2025

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Tags

Virology and viral diseases

Abstract

 The present work represents a trial for preparation and evaluation of a combined vaccine against Newcastle disease (ND) and necrotic enteritis (NE) as a viral and bacterial diseases affecting poultry industry in a dramatic form. The obtained results showed that the prepared vaccine was stable; free from foreign contaminants; safe and immunogenic for vaccinated chickens. The comparison between the efficacy of single ND and NE vaccines with the efficacy of the prepared combined ND and NE vaccine revealed that both vaccines were Immunogenic inducing protection against the challenge with virulent strain of ND virus of 87 and 93% in single and combined vaccines respectively. Non vaccinated chickens were unable to withstand the virulent strain of ND virus. Haemagglutination inhibition test (HI) for estimation of ND antibodies was confirmed by the results of challenge test. It was noticed that the combined vaccine induced higher antibody titer and higher protection than those induced by single vaccine. On the other hand, using serum neutralization test for estimation of the antibodies against NE revealed that the antibody titer was higher in combined vaccine than single vaccine. So, it could be suggested that the combined ND and NE vaccine is preferable than the single vaccines.  

DOI

10.21608/vmjg.2011.368231

Authors

First Name

Salman

Last Name

A

MiddleName

-

Affiliation

Veterinary Serum and Vaccine Research Institute; Abassia,Cairo

Email

-

City

-

Orcid

-

First Name

Hanaa

Last Name

Mostafa

MiddleName

-

Affiliation

Central Laboratory for Evaluation of Veterinary Biologics

Email

-

City

-

Orcid

-

First Name

Ghada

Last Name

Sadek

MiddleName

-

Affiliation

Central Laboratory for Evaluation of Veterinary Biologics

Email

-

City

-

Orcid

-

First Name

Hussein

Last Name

S

MiddleName

-

Affiliation

Veterinary Serum and Vaccine Research Institute; Abassia,Cairo

Email

-

City

-

Orcid

-

First Name

Elham

Last Name

El-Ebiary

MiddleName

-

Affiliation

Central Laboratory for Evaluation of Veterinary Biologics

Email

-

City

-

Orcid

-

First Name

Khodeir

Last Name

H

MiddleName

-

Affiliation

Veterinary Serum and Vaccine Research Institute; Abassia,Cairo

Email

-

City

-

Orcid

-

First Name

Makharita

Last Name

A

MiddleName

-

Affiliation

Central Laboratory for Evaluation of Veterinary Biologics

Email

-

City

-

Orcid

-

Volume

59

Article Issue

3

Related Issue

49193

Issue Date

2011-07-01

Receive Date

2024-07-20

Publish Date

2011-07-01

Page Start

65

Page End

72

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 59_Issue 3_Pages 65-72.pdf

PDF . 1.4MB

Link

https://vmjg.journals.ekb.eg/article_368231.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=368231

Order

368,231

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Preparation and Evaluation of a Combined Inactivated Oil Emulsion Vaccine against Newcastle and Chicken Necrotic Enteritis Diseases

Details

Type

Article

Created At

23 Dec 2024