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368064

ADVERSE EFFECTS OF PHOSMET ON MALE FERTILITY IN RATS

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Last updated: 03 Jan 2025

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Miscellaneous

Abstract

Assessments of the reproductive toxicity of organophosphorus insecticides are important public health issues. The adverse reproductive effects of one of the commonly used organophosphorus members, namely; phosmet on male rats were investigated. The tested insecticide was given orally to male rats at five dosage levels (phosmet, 0.81, 1.62, 3.25, 6.5 and 13 mg kg-1 b.wt) for 60 consecutive days. Plasma testosterone levels, sex organs weights, semen quality as well as histopathological finding of testis were the criteria used to evaluate the reproductive efficiency of the treated rats. A dose-dependant decrease was observed in the weights of the most genital organs, sperm cell concentrations and sperm motility associated with a significant increase in the percentage of dead morphologically abnormal spermatozoa of treated rats. Plasma testosterone level was declined significantly in phosmet treated groups at 3.25, 6.5 and 13 mg kg-1 b.wt. Sperm cell concentrations was severely affected by phosmet at high dose level (3.25, 6.5 and 13 mg kg-1 b.wt,). Histopathological examination of the testes revealed a mild, moderate and severe histopathological changes in rats treated with phosmet and severity was dose dependent. It is concluded that, phosmet induced adverse effects on male rats fertility by impairing both testicular function and structure.

DOI

10.21608/vmjg.2011.368064

Authors

First Name

A

Last Name

Al Taher

MiddleName

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Affiliation

College of Veterinary Medicine and Animal Resources, King Faisal University

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Orcid

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Volume

57

Article Issue

4

Related Issue

49190

Issue Date

2009-10-01

Receive Date

2024-07-18

Publish Date

2011-10-01

Page Start

769

Page End

781

Print ISSN

1110-1423

Online ISSN

2537-1045

Link

https://vmjg.journals.ekb.eg/article_368064.html

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https://vmjg.journals.ekb.eg/service?article_code=368064

Order

368,064

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

ADVERSE EFFECTS OF PHOSMET ON MALE FERTILITY IN RATS

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Article

Created At

23 Dec 2024