An autoclaved cortical bone xenografts of goat cadavers (ACXG) as well as fresh cortical autograft (control FCAG) were successfully used in reconstruction of an experimentally induced segmental femoral defect in canine model. Clinical and radiological assessments were carried out at different periods post-operatively. The obtained results were encouraging and very promising in terms of early return to full limb function at 4-6 weeks post-operatively, cortical union with remodeling were completed at 6 months post-operatively and complete acceptance and incorporation of the graft into the host bone was recorded at 12 months post-operatively. Hence the autoclaved cortical bone xenografts of goat cadavers can offer a worthwhile alternative fo fresh cortical autografts to veterinary orthopedists.