Combined Intramedullary Pinning and External Skeletal Fixation (CIPEF) together with open reduction approach were successful in repair of comminuted diaphyseal femoral fractures in heavy weight breeds of dogs (N= 15 and weight> 55 kg). In the present study comminuted fractures were classified into two types; short and long. In the former, the seat of comminution restricted only on one third of the femoral diaphysis. While in the latter the seat of comminution was started at mid-shaft and extended to a short distance proximally or distally. The results emphasized on the necessity of 4 to 5 external fixator pins combined with two intramedullary pins for reconstruction of long comminuted fracture. However, in short type, 3 external fixator pins combined with two intramedullary pins were sufficient to achieve rigid stability at the fracture site. The use of CIPEF and open reduction approach gave very promising results in terms of, adequate alignment without deformities, rigid stability with minimal callus formation and early return to full limb function without fracture disease.