Chicken necrotic enteritis vaccine was used to vaccinate chicks in a mutual manner with zinc bacitracin or oligosaccharides (MOS). The study included four groups of chicks (50 birds/group). The first group was vaccinated with chicken necrotic enteritis vaccine and zinc bacitracin. The second group was vaccinated with chicken necrotic enteritis vaccine and oligosaccharides while the third group was vaccinated with chicken necrotic enteritis vaccine only. Fourth group was kept as unvaccinated control. The obtained results suggest that the use of (MOS) with necrotic enteritis vaccine represent a practical preventive method against necrotic enteritis in broiler chicken and improve production performance.