Organophosphorous pesticides such as chlorpyrifos (CPF) are substances used worldwide for agricultural purposes. CPF induce oxidative stress leading to the generation of free radicals. The purpose of this study was to assess the biochemical role of wheat germ and grape seed oils on the kidney function tests and the induced by moreover the oxidative stress alteration chlorpyrifos in rats, heamatological, lipid profile. Throughout this study a total number of 70 rats were subjected to experimentation for 4 weeks and divided into 7 groups. The results demonstrated that there were significant decrease in the total counts of RBC's, WBC's, _ erythrocyte indices, hemoglobin concentration, hematocrit level in experimental rats fed diets containing low and high levels of CPF. CPF caused a significant increase in serum creatinine and urea the increase reached 211.39% and 104.29, % respectively for high dose of CPF received rats as compared to control rats.The treatments with, wheat germ oil, grape seed oil at the tested doses significantly reduced serum creatinine by 27.84% and 15.19% for G6 and G4 respectively. Concerning the values of lipid profile measurement, it was clear that low and high dose CPF received rats induced a significant increase in the level of serum total lipid, total cholesterol and triacylglycerols, also this reflects an elevation in the level LDL-C, VLDL-C and LDL/HDL ratio. Meanwhile, wheat germ oil supplementation reduced the serum LDL-C, VLDL-C and LDL/HDL ratio and increased serum HDL-C. It can be concluded that wheat germ oil and grape seed oils, used are valuable natural antioxidants for protecting against oxidative toxic effects of CPF and cell damage caused by toxic chemicals