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366946

Role of stabilizers in preparation of a potent sheep pox vaccine

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Virology and viral diseases

Abstract

Production of live attenuated sheep pox vaccine sustained the elevated temperatures during freeze-drying, transportation storage and vaccination in unequipped tropical and subtropical zones of the world, is highly recommended. For this reason, eight stabilizer formulas were individually used for preparation of eight sheep pox vaccines, which were lyophilized and then titrated and accordingly four vaccine formulas were eventually selected that should be tested for thermo protectivity to select the best stabilized vaccine. These selected vaccines were tested for sterility; potency (vaccination and challenge) and safety in susceptible sheep. The collected blood sera were subject to serological examination for estimating the antibody response by ELISA. The results proved transcendence of sheep pox vaccines stabilized with 10% trehalose alone or in combination with 5% lactalbumin hydrolyste in the thermoprotectivey, thereby improvement vaccination efficacy.

DOI

10.21608/vmjg.2024.366946

Authors

First Name

Christine

Last Name

Mikhael

MiddleName

-

Affiliation

Department of Pox, Veterinary Sera and Vaccines Research Institute, Abbassia, Cairo

Email

-

City

-

Orcid

-

First Name

A

Last Name

El-sanousi

MiddleName

-

Affiliation

Department of Virology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

I

Last Name

Reda

MiddleName

-

Affiliation

Department of Virology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

S

Last Name

Rizkallah

MiddleName

-

Affiliation

Department of Pox, Veterinary Sera and Vaccines Research Institute, Abbassia, Cairo

Email

-

City

-

Orcid

-

Volume

58

Article Issue

1

Related Issue

49150

Issue Date

2010-01-01

Receive Date

2024-07-14

Publish Date

2024-01-01

Page Start

1

Page End

13

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 58_Issue 1_Pages 1-13.pdf

PDF . 5.1MB

Link

https://vmjg.journals.ekb.eg/article_366946.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=366946

Order

366,946

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Role of stabilizers in preparation of a potent sheep pox vaccine

Details

Type

Article

Created At

23 Dec 2024