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363161

Histopathological and clinicopathological studies on the antioxidant effect of gold nanoparticles in diethyInitrosamine induced hepatocarcinogenesis in rats

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Pathology / oncology

Abstract

This study investigated the antioxidant and therapeutic effect of gold nanoparticles (GNPs) against diethylnitrosamine (DENA) induced hepatocarcinogenesis. 24 rats were divided into four groups. The first group kept as a negative control group without any treatments. The second group received single intraperitoneal injection of DENA (200 mg/kg) followed by weekly subcutaneous injections of carbon tetrachloride (3 ml/kg) for 10 weeks and kept as a positive control group. The third group was intoxicated by DENA and CCLA as the second group then treated by I.p. Injection of 0.075 mg free GNPs kg-1 twice (at day, 0 and 3) then retreated with the same dose after 21 days. The fourth group received the same dose of GNPs as in third group. The results showed that group injected with DENA expressed high levels of lipid peroxidation (MDA) accompanied by significantly decreased levels of antioxidants (reduced glutathione and Catalase) when compared with the control group, on the other hand there was significant decrease in MDA and Increase in antioxidants in GNPs treated group. Concomitantly, the improvement of histopathological alterations induced by DENA in livers of GNPS treated groups was observed. In conclusion, these results suggested a positive hepatotherapeutic and antioxidant effect of GNPs by decreasing lipid peroxidation and enhancing the levels of antioxidants in DENA-induced hepatocarcinogenesis by reducing the formation of free radicals.

DOI

10.21608/vmjg.2016.363161

Keywords

antioxidants, Hepatocarcinogenesis, Diethylnitrosamine, Gold nanoparticles

Authors

First Name

Eman

Last Name

Hassanen

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

eme_amr@hotmail.com

City

-

Orcid

-

First Name

Reda

Last Name

Korany

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

reda_pathology@cu.edu.eg

City

-

Orcid

-

First Name

Taher

Last Name

Salah Eldin

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

A

Last Name

Bakeer

MiddleName

-

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

Volume

62

Article Issue

2

Related Issue

47597

Issue Date

2016-04-01

Receive Date

2024-07-01

Publish Date

2016-04-01

Page Start

73

Page End

80

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 62_Issue 2_Pages 73-80.pdf

PDF . 3.2MB

Link

https://vmjg.journals.ekb.eg/article_363161.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=363161

Order

363,161

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Histopathological and clinicopathological studies on the antioxidant effect of gold nanoparticles in diethyInitrosamine induced hepatocarcinogenesis in rats

Details

Type

Article

Created At

23 Dec 2024