Chronic snuffles was a common problem in cats. A total number of 15 Persian cats (3 apparently healthy and 12 clinically diseased cases with chronic snuffing) of 2.7 to 4.2 years admitted to faculty of veterinary medicine, Cairo university hospital and private veterinary clinics. The apparently healthy group was showed no respiratory manifestations and normal breath sounds on auscultation. Mucous membranes were faint rosy red. Superficial lymph nodes were free. Bacteriological examination was negative. Chronic snuffles cats (12 cases) were divided into 2 subgroups according to clinical presentation and systemic reactions. The first subgroup was chronic snuffler cats without systemic reaction (3 cases) which showed chronic snuffling, nasal discharges, ocular discharges since 3 months. Tracheal auscultation was revealed crackles. No significant change in respiratory rate, pulse rate or rectal temperature in comparison apparently healthy group. Mucous membranes were faint rosy red. Superficial lymph nodes were enlarged. No abnormal lung sounds were recorded. Bacteriological examination was revealed Pasteurella multocida in the 3 chronic snuffles cats. The first was susceptible to clindamycin, the second was susceptible to ciprofloxacin, the third was susceptible to neomycin and all 3 cats showed multidrug resistance. The second subgroup was Chronic snuffles cats with systemic reaction (9 cases). This group was showed open mouth breath (dyspnea), chronic snuffling, nasal discharges, ocular discharges since 3 weeks. Respiratory rate, pulse rate and rectal temperature were displayed significant increase in comparison to apparently healthy group. Bacteriological examination revealed 9 Staph. aureus. All group was susceptible to amoxicillin-clavulinic acid in vitro and showed multidrug resistance. In vivo treatment of chronic snuffles subgroups were responded to antibiotics of the present in-vitro study except one case in subgroup 1 and one case in subgroup 2.