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363288

Antimicrobial, Analgesic and Anti-inflammatory Effects of Euphorbia Helioscopia Plant (Al-jejan) Extracts

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Pharmacology

Abstract

The Antimicrobial, analgesic and anti-inflammatory activities of Euphorbia helioscopia (EH) aqueous and ethanolic extracts were evaluated. The effect of both extracts of EH was tested against some Gram positive, Gram negative and some fungi in vitro. Microtiter plates containing serial dilutions of each extract of EH were inoculated with the tested microorganisms and Microtiter MIC assay was used. The analgesic activity was evaluated against thermally and chemically induced pain in mice, using hot plate and acetic acid-induced writhing methods, respectively. The anti-inflammatory effect was investigated by induction of paw edema and swelling using formalin solution in rats. The results showed that aqueous and ethanolic extracts of EH exhibit effective antibacterial and antifungal activities. Both aqueous and ethanol extracts of EH in doses 250 and 500 mg/kg induced potent analgesic activity, in a dose-dependent manner, using both hot plate and writhing tests. Both extracts of EH induced a marked anti-inflammatory activity as it significantly reduced the paw edema and swelling induced by formalin in paw of rats. In conclusion, aqueous and ethanolic extracts of Euphorbia helioscopia produce antimicrobial, analgesic and anti- inflammatory effects. These results affirm the therapeutic uses of Euphorbia helioscopia in folk medicine for the treatment of bacterial infections, pain and inflammation.

DOI

10.21608/vmjg.2016.363288

Keywords

Euphorbia helioscopia, Antimicrobial, analgesic, Anti-inflammatory

Authors

First Name

Abdullah

Last Name

AlSafaf

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Hama University

Email

-

City

-

Orcid

-

First Name

Mostafa

Last Name

Shalaby

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Abdullrazzak

Last Name

Hamoweih

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Hama University

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Samir

MiddleName

-

Affiliation

Microbiology Department, Faculty of Veterinary Medicine, Cairo University

Email

ahmed.samir@cu.edu.eg

City

-

Orcid

-

Volume

62

Article Issue

1

Related Issue

47596

Issue Date

2016-01-01

Receive Date

2024-07-02

Publish Date

2016-01-01

Page Start

69

Page End

75

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 62_Issue 1_Pages 69-75.pdf

PDF . 3.0MB

Link

https://vmjg.journals.ekb.eg/article_363288.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=363288

Order

363,288

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Antimicrobial, Analgesic and Anti-inflammatory Effects of Euphorbia Helioscopia Plant (Al-jejan) Extracts

Details

Type

Article

Created At

23 Dec 2024