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363264

A canine model of carbon tetrachloride (ccl4) induced liver cirrhosis: II.Ultrasonographic and histopathological study

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Surgery, anesthesia, diagnostic imaging

Abstract

Liver cirrhosis is a diffuse state with replacement of the normal lobular architecture by abnormal nodules and fibrous septa. The Laennec staging system subdivides cirrhosis into 3 groups (4A,4B,4C) based on the thickness of fibrous septa and the size of nodules.  This study aimed to assess the degree of liver cirrhosis through ultrasonographical and histopathological study after the administration of CCl4, in order to establish a canine model of liver cirrhosis for further research work. Experimental induction of liver cirrhosis was carried on 18 skeletally mature mongrel dogs using carbon tetrachloride (CCl4) for 16 weeks; dogs were evaluated for cirrhosis using ultrasonographical examination with portal vein (PV) and hepatic vein (HV) diameter, histopathological changes every 4 weeks and finally postmortem examination. Liver fibrosis was subdivided through liver biopsy under the guidance of ultrasonography using the Laennec staging system. Liver cirrhosis was confirmed by abnormal liver ultrasononography with portal hypertension, liver cirrhosis on biopsy sample was scored 4A,4B,4C based on the thickness of the fibrous septa and the size of nodules according to Laennec staging system. The degree of liver cirrhosis was recorded through ultasonographical and histopathological examination.

DOI

10.21608/vmjg.2016.363264

Keywords

dogs, CCl4, Liver, Cirrhosis, fibrosis staging

Authors

First Name

Marwa

Last Name

Hassan

MiddleName

-

Affiliation

Dept of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt.

Email

-

City

-

Orcid

-

First Name

Omar

Last Name

El-Tookhy

MiddleName

-

Affiliation

Dept of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt.

Email

-

City

-

Orcid

-

First Name

Elham

Last Name

Hassan

MiddleName

-

Affiliation

Dept of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt.

Email

elhamhassan@cu.edu.eg

City

-

Orcid

-

First Name

Sabry

Last Name

Abdelfattah

MiddleName

-

Affiliation

Dept of Medical Biochemistry and Molecular Biology, Faculty of Med, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Gehan

Last Name

Shehab

MiddleName

-

Affiliation

Dept of Pathology, Animal Health Research Institute, Ministry of Agriculture, Egypt.

Email

-

City

-

Orcid

-

First Name

Ashraf

Last Name

Shamaa

MiddleName

-

Affiliation

Dept of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

Email

shamaa_61@yahoo.com

City

-

Orcid

-

Volume

62

Article Issue

1

Related Issue

47596

Issue Date

2016-01-01

Receive Date

2024-07-02

Publish Date

2016-01-01

Page Start

27

Page End

34

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 62_Issue 1_Pages 27-34.pdf

PDF . 3.0MB

Link

https://vmjg.journals.ekb.eg/article_363264.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=363264

Order

363,264

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

A canine model of carbon tetrachloride (ccl4) induced liver cirrhosis: II.Ultrasonographic and histopathological study

Details

Type

Article

Created At

23 Dec 2024