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363261

A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Surgery, anesthesia, diagnostic imaging

Abstract

The liver is a vital organ of vertebrates and plays a major role in metabolism in addition to other numerous functions in the living body, including regulation of glycogen storage, decomposition of red blood cells, plasma protein synthesis, hormone production, and detoxification. Damage of hepatic cells “Liver cirrhosis" is apotentially life-threatening condition. This could be accredited to a variety of pharmacological agents, viruses, alcohol abuse, autoimmune inflammation and exposure to metabolic metals such as iron, copper and other toxic substances. Carbon tetrachloride (CCl4)is a known highly hepatotoxic agent. This study aimed to assess the degree of liver cirrhosis through clinical and biochemical and hematological analysis after the administration of CCl4 in order to establish a canine model of liver cirrhosis for further research work. Eighteen skeletally mature mongrel dogs received weekly oral administration of CCl4. (ImI/kg 98%) for 16 weeks. Dogs were examined for symptoms of liver cirrhosis and the degree of cirrhosis was recorded through clinical and biochemical and hematological tests. Dogs were of clinical manifestation of liver insufficiency with abnormal hematological and biochemical tests values so we can conclude that, the levels of serum markers of the liver (liver biochemical tests) and other hematological parameters can be taken as a staging indicator of liver cirrhosis.

DOI

10.21608/vmjg.2016.363261

Keywords

dogs, CCl4, Liver, Cirrhosis, hematological and biochemical tests

Authors

First Name

Marwa

Last Name

Hassan

MiddleName

-

Affiliation

Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Elham

Last Name

Hassan

MiddleName

-

Affiliation

Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

Email

elhamhassan@cu.edu.eg

City

-

Orcid

-

First Name

Omar

Last Name

El-Tookhy

MiddleName

-

Affiliation

Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Sabry

Last Name

Abdelfattah

MiddleName

-

Affiliation

Depart of Med Biochemistry and Molecular Biology, Faculty of Mede, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Gehan

Last Name

Shehab

MiddleName

-

Affiliation

Depart of Pathology, Animal Health Research Institute, Ministry of Agriculture, Egypt

Email

-

City

-

Orcid

-

First Name

Ashraf

Last Name

Shamaa

MiddleName

-

Affiliation

Depart of Surgery, Anesthesiology and Radiology, Faculty of Vet Med, Cairo University, Egypt

Email

shamaa_61@yahoo.com

City

-

Orcid

-

Volume

62

Article Issue

1

Related Issue

47596

Issue Date

2016-01-01

Receive Date

2024-07-02

Publish Date

2016-01-01

Page Start

21

Page End

25

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 62_Issue 1_Pages 21-25.pdf

PDF . 2.0MB

Link

https://vmjg.journals.ekb.eg/article_363261.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=363261

Order

363,261

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

A Canine model of carbon tetrachloride (Ccl4) induced liver cirrhosis: I. Clinical, hematological and biochemical Evaluations

Details

Type

Article

Created At

23 Dec 2024