This study aimed to investigate the influence of treatment with silver oxide nanoparticles
intrauterine infusion on ovarian and uterine blood flow, cortisol, estradiol (E2) and interlukine-10 (IL-10). Mares (N=8), diagnosed positive to endometritis, were examined by Doppler ultrasonography. Blood samples were collected prior to each ultrasound exam.. Blood sera were used to assay cortisol, E2, and IL-10. The uterine and ovarian arteries' time average mean velocity (TAMV) and blood flow volume(BFV) were determined. Mares were infused intrauterine with 50 mg/kg body weight of silver oxide nanoparticles on Day 7(from ovulation ) and another dose on Day 14 from ovulation . On day 21 from ovulation , there were significant decreases in BFV and TAMV values of the uterine (P< 0.001; P< 0.05, respectively) and ovarian arteries (P< 0.0001). A non-significant change in the cortisol and IL-10 was noticed throughout the treatment. In conclusion, silver oxide nanoparticles modulated uterine and ovarian blood flow in endometritis suffered mares on day 21 post-treatment.