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268751

Morphological and Laboratory improvement of Cisplatin - induced azoospermia using adipose derived mesenchymal stem cells in a rabbit model

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Anatomy
Theriogenology / reproductive technology

Abstract

The testes are highly susceptible to the adverse effects of chemotherapy and radiation at all stages of life. Exposure to these threats mainly occurs during cancer treatment and as an occupational hazard in radiation centers. The present study investigated the regenerative ability of adipose-derived mesenchymal stem cells (ADMSCs) against the adverse effects of cisplatin on the structure and function of the testes. New Zealand white male rabbits (N = 15) were divided into three groups of five: a negative control group (no treatment), a cisplatin group (single dose of cisplatin into each testis), and a cisplatin with ADMSCs group (cisplatin was injected followed by an ADMSC injection three days later). On day 45 post-treatment, serum testosterone levels were evaluated, and the testes and epididymis were collected for histology, and epididymal sperm analysis. Cisplatin caused damage to the testicular tissue and decreased serum testosterone levels and epididymal sperm counts The ADMSC-treated group displayed a moderate epididymal sperm count, suitable hormone levels, and enhanced testicular tissue morphology. ADMSCs treatment enhanced damaged testicular tissue and modified pathological changes caused by cisplatin.

DOI

10.21608/vmjg.2022.170699.1016

Keywords

Testicular degeneration, sperm analysis, cisplatin side-effects

Authors

First Name

Hamdy

Last Name

Y. Ismail

MiddleName

-

Affiliation

Department of Anatomy and embryology, Faculty of Veterinary medicine, Cairo university, Giza,Egypt

Email

hamdy.yossef@cu.edu.eg

City

-

Orcid

-

First Name

Nora

Last Name

A. Shaker

MiddleName

-

Affiliation

Department of Anatomy and embryology, Faculty of Veterinary medicine, Cairo university, Giza,Egypt

Email

dr_norashaker@cu.edu.eg

City

-

Orcid

-

First Name

Shaymaa

Last Name

Hussein

MiddleName

-

Affiliation

Department of Histology, Faculty of Veterinary Medicine, Cairo University

Email

shaymaahussein77@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Fathi

MiddleName

-

Affiliation

Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Egypt

Email

mido2022@yahoo.com

City

-

Orcid

-

First Name

Hamdy

Last Name

Rizk

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Email

hamdyrezk81@cu.edu.eg

City

-

Orcid

-

First Name

Y.R.

Last Name

Wally

MiddleName

-

Affiliation

Department of Anatomy and embryology, Faculty of Veterinary medicine, Cairo university, Giza,Egypt

Email

yr.wally82@gmail.com

City

-

Orcid

-

Volume

68

Article Issue

1

Related Issue

39232

Issue Date

2022-12-01

Receive Date

2022-10-25

Publish Date

2022-12-01

Page Start

80

Page End

94

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 68_Issue 1_Pages 80-94.pdf

PDF . 708.3kB

Link

https://vmjg.journals.ekb.eg/article_268751.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=268751

Order

6

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Morphological and Laboratory improvement of Cisplatin - induced azoospermia using adipose derived mesenchymal stem cells in a rabbit model

Details

Type

Article

Created At

23 Dec 2024