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355275

Modulatory Effect of Origanum Majorana L on Changes Induced: By Bisphenol A in Female ups Rats

Article

Last updated: 03 Jan 2025

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Tags

Biochemistry

Abstract

Environmental contaminants play an important role in the inheritance of female reproductive dysfunction. Nutraceuticals are able to influence female reproductive function and could be considered a protective agent. The present study investigated the potential effect of the Origanum majorana L (OML) on the oxidative changes induced by Bisphenol A (BPA) in female| offspring. 48 female albino rats were divided into 2 groups. Group I: female rats were given orally 50 mg/kg of BPA / day during gestation and/or lactation periods, and group IJ OML was given orally to dams in a dose of 250 mg /kg daily 3 weeks before BPA administration each as alone or in combination with BPA. At postnatal day 60 (PND 60) serum estradiol (E2): triacylglycerol (TAG), total cholesterol (TC), HDL —cholesterol (HDL-C), LDL- cholesterol (LDL-C), VILDL-cholesterol: (VLDL-C) levels were assayed in female pups. Also, malondialdehyde (MDA) and glutathione (GSH) contents, Superoxide: dismutase (SOD), Catalase (CAT), and Glutathione-s- transferase (GST) activities were estimated in ovarian tissue of pups. BPA exposure resulted in decreased serum E2 and HDL-C levels, ovarian GSH content and SOD; CAT and GST activities. On the other hand BPA increased level of serum TAG,TC, LDL-C, VLDL-C and ovarian MDA content. The observed: antioxidant and hypolipidemic effect of OML co-administration to dams modulated the adverse effects induced by BPA in a time- dependent manner in female pups. In conclusion; the modulatory effect of OML on pup's adverse oxidative changes induced by BPA showed its potential as a protective agent against female reproductive dysfunction.

DOI

10.21608/vmjg.2017.355275

Keywords

Origanum majorana L, bisphenol A, estradiol, Oxidative Stress, Antioxidant enzymes

Authors

First Name

Hanan

Last Name

El Henafy

MiddleName

-

Affiliation

Medical Laboratory Department, Faculty of Applied Medical Sciences, October 6 University

Email

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City

-

Orcid

-

First Name

Marwa

Last Name

Ibrahim

MiddleName

-

Affiliation

Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

Samy

Last Name

Abd El Aziz

MiddleName

-

Affiliation

Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Gouda

MiddleName

-

Affiliation

Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University.

Email

-

City

-

Orcid

-

Volume

63

Article Issue

4

Related Issue

1472

Issue Date

2017-10-01

Receive Date

2024-05-20

Publish Date

2017-10-01

Page Start

57

Page End

65

Print ISSN

1110-1423

Online ISSN

2537-1045

Article File

VMJG_Volume 63_Issue 4_Pages 57-65.pdf

PDF . 5.5MB

Link

https://vmjg.journals.ekb.eg/article_355275.html

Detail API

https://vmjg.journals.ekb.eg/service?article_code=355275

Order

355,275

Type

Original Article

Type Code

544

Publication Type

Journal

Publication Title

Veterinary Medical Journal (Giza)

Publication Link

https://vmjg.journals.ekb.eg/

MainTitle

Modulatory Effect of Origanum Majorana L on Changes Induced: By Bisphenol A in Female ups Rats

Details

Type

Article

Created At

23 Dec 2024