Human respiratory problems have been linked to Candidatus Ornithobacterium hominis (O. hominis), which was discovered in nasopharyngeal swabs from all over the world. The largest family in the Bacteroidetes phylum is Flavobacteriaceae, which includes O. hominis, a recently discovered member. This family has 90 genera and hundreds of species, including important human infections like Elizabethkingia meningoseptica and Capnocytophaga canimorsus. In this review, we summarized the sum of the previous works done on the OH genome to determine the antimicrobial resistance genes and virulence factors that are present in the core genome. We discussed the initial description of the culture conditions used to isolate this bacterium. A deeper understanding of the therapeutic significance of this species is expected to become easier with the availability of an easily reproducible culture method. We also discussed the phylogenetic relationship of O. hominis and O. rhinotracheal, which shows close genus relationships indicated by the two genomes' approximately 40% amino acid similarity over 50% of their length.