Cleome amblyocarpa (Barratte & Murb.) is widely growing in desert sandy habitats of Sinai, Egypt, and many parts of North Africa. Along the history, C. amblyocarpa, family Cleomaceae is frequently used to treat a variety of illnesses in traditional medicine. The plant was selected based on the outstanding results of a previous biological study that Correspondence Author conducted on a plant extract of C. amblyocarpa. : Use as anticancer, anti-inflammatory, gastrointestinal disorders, anti-diabetic, antimicrobial and anthelmintic. Several species of Cleomaceae have been reported to contain numerous phytochemicals such as triterpenoids, sterols, flavonoids, saponins, alkaloids, polyacetylenes and coumarins. The phytochemical components of this significant and useful genus are highlighted in this review, along with its several documented biological functions. In order to maximize the medicinal and nutritional benefits of C. amblyocarpa, more research on the active ingredients in this plant is necessary. This is because the plant extract is unquestionably a good source of components that strengthen health and may be utilized for both nutritional and therapeutic purposes.