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Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Biochemistry and molecular biology

Abstract

Diabetic nephropathy (DN) stands out as one of the most significant complications of diabetes mellitus, and it is a primary contributor to end-stage kidney disease globally. The progression of DN is complex, involving intricate interplays, including oxidative stress, inflammation, fibrosis, and cellular apoptosis. Recently, scientific investigations have emphasized the significant role of the sigma-1 receptor (S1R) and nuclear factor erythroid 2-related factor 2 (Nrf2) in mitigating these detrimental effects. Scientific evidence indicated that the activation of S1R could effectively diminish cellular oxidative stress, inflammation, and cell death, alleviating renal damage in diabetic nephropathy. Nrf2, a key regulator of antioxidant responses, protects renal cells from oxidative injury and modulates inflammatory responses. Targeting S1R and Nrf2 may provide novel therapeutic approaches for managing diabetic nephropathy. This review offers a detailed overview of the pathophysiological mechanisms underlying DN, focusing on the S1R/Nrf2 axis and its potential as a promising therapeutic target for diabetic nephropathy.

DOI

10.21608/rpbs.2024.327923.1331

Keywords

diabetic nephropathy, Oxidative Stress, Inflammation, apoptosis, S1R/Nrf2

Authors

First Name

Dalia

Last Name

Asal

MiddleName

mohamed

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

daliaasal_staff@pharm.suez.edu.eg

City

-

Orcid

-

First Name

Alaa

Last Name

Wahba

MiddleName

S.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

alaa.samir@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0002-2600-9965

First Name

Reem

Last Name

Hazem

MiddleName

-

Affiliation

Pharmacology & toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

Email

reem_ahmed@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0002-7667-9561

First Name

Noha

Last Name

Mesbah

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

noha_mesbah@pharm.suez.edu.eg

City

-

Orcid

0000-0002-8863-968X

First Name

Dina

Last Name

Abo-El-Matty

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

dinawahadan@yahoo.com

City

Ismailia

Orcid

0000-0002-6074-2714

First Name

Asmaa

Last Name

Ramadan

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

asmaa.ramdan@pharm.suez.edu.eg

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

47567

Issue Date

2024-05-01

Receive Date

2024-10-12

Publish Date

2024-05-01

Page Start

179

Page End

190

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 8_Issue 1_Pages 179-190.pdf

PDF . 880.6kB

Link

https://rpbs.journals.ekb.eg/article_390269.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=390269

Order

390,269

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Pathophysiological Mechanisms of Diabetic Nephropathy: Role of S1R/Nrf2 Antioxidant Axis

Details

Type

Article

Created At

23 Dec 2024