Obesity  and  its  associated  complications  are  reaching  epidemic  proportions worldwide.  Obesity  is  closely  linked  with  the  development  of  serious  chronic diseases,  mainly  type  2  diabetes  mellitus,  cardiovascular  disease,  and nonalcoholic  fatty  liver  disease  and  several  malignancies.  Acacia  nilotica  is  an important  ornamental  and  medicinal  plant  of  tropical  and  sub-tropical  regions that  belongs  to  family  Fabaceae  of  genus  Acacia.  An  exhaustive  survey  of literature  has  revealed  that  tannins,  flavonoids,  alkaloids,  fatty  acids  and polysaccharides  (gums)  constitute  major  classes  of  phytoconstituents  of  A. nilotica.  Previous  studies  revealed  significant  anti-inflammatory,  antioxidant, antidiarrheal,  antihypertensive  and  antispasmodic,  antibacterial,  anthelmintic, antiplatelet aggregator and anticancer activities.