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353892

Use of eosin for spectroscopic determination of Adefovir dipivoxil

Article

Last updated: 25 Feb 2025

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Subjects

-

Tags

Analytical chemistry

Abstract

This paper elucidates a new spectrofluorometric method for the determination of Adefovir Dipivoxil in its pharmaceutical dosage form using Eosin, the colored ion - pair complex was produced at λ em 544 nm and excitation at λ ex 267 in acetate buffer solution with a pH of 3.5. The linearity range was 0.1 – 1.5 µg/ml, with a percentage recovery of 99.31,
and detection limit of 0.032 µg/ml.  The quantification limit was 0.097 µg/ml. The method was successfully applied to determine Adefovir Dipivoxil in its pharmaceutical dosage form. The method was Sensitive, rapid and cost-effective, demonstrating ease of application suitable for routine quality control analysis. 

DOI

10.21608/rpbs.2024.270833.1270

Keywords

eosin, Spectroscopic determination, Adefovir dipivoxil

Authors

First Name

Shaimaa

Last Name

Elsayed

MiddleName

Mohamed

Affiliation

Demonstrator at hue University faculty of pharmacy

Email

shelsied@horus.edu.eg

City

-

Orcid

-

First Name

Alaa

Last Name

El-Gendy

MiddleName

Mohamed

Affiliation

Professor of Pharmaceutical Analytical Chemistry Faculty of Pharmacy - Suez Canal University

Email

alaa.elgindy@hotmail.com

City

Ismailia

Orcid

-

First Name

Yasser

Last Name

El-shabrawy

MiddleName

-

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Email

yshabrawy_2000@yahoo.com

City

-

Orcid

-

First Name

ElSayed

Last Name

Ibrahim

MiddleName

A.

Affiliation

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

Email

eibrahim@pharm.suez.edu.eg

City

el esmailia

Orcid

-

Volume

8

Article Issue

1

Related Issue

47567

Issue Date

2024-05-01

Receive Date

2024-02-17

Publish Date

2024-05-01

Page Start

70

Page End

79

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 8_Issue 1_Pages 70-79.pdf

PDF . 920.0kB

Link

https://rpbs.journals.ekb.eg/article_353892.html

Detail API

http://journals.ekb.eg?_action=service&article_code=353892

Order

353,892

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Use of eosin for spectroscopic determination of Adefovir dipivoxil

Details

Type

Article

Created At

23 Dec 2024