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353888

Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry and molecular biology

Abstract

Osteoarthritis (OA) is a chronic degenerative joint disease, characterized by progressive degradation and loss of articular cartilage, subchondral bone sclerosis, inflammation, and osteophyte formation. Edema, chronic pain, and limited joint movement are the major signs of OA. Recent studies have shown that it affects 240 million aged people globally, and about 10% of males and 18% of women over the age of 60. Because of this, it is now the main factor in pain, disability, and decreased adult work performance throughout the world. OA can be regarded as a multifactorial disease, with several factors including aging, genetic predisposition, epigenetic control, inflammation, obesity, and trauma being involved in its pathophysiology. Signal transducer and activator of transcription 3 (STAT3) has been described as one of the critical factors involved in the initiation and development of inflammatory responses in OA. Previous studies have provided evidence that microRNAs (miRNAs) play a major role in the regulation of STAT3 expression through binding to the 3′ untranslated region (3′UTR) of STAT3 mRNA

DOI

10.21608/rpbs.2024.257294.1259

Keywords

osteoarthritis, STAT3, miR-452-3p

Authors

First Name

Dina

Last Name

Mohamed

MiddleName

Abdelhakim

Affiliation

Department of biochemistry and molecular biology, faculty of pharmacy, Suez canal university, Ismailia, Egypt.

Email

dina_hakim@pharm.suez.edu.eg

City

-

Orcid

-

First Name

Alaa

Last Name

Wahba

MiddleName

Samir

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

alaa.samir@pharm.suez.edu.eg

City

-

Orcid

0000-0002-2600-9965

First Name

Eman

Last Name

Mehanna

MiddleName

T.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt

Email

eman.taha@pharm.suez.edu.eg

City

-

Orcid

0000-0003-2759-2889

First Name

Mohamed

Last Name

Mehanna

MiddleName

Taha

Affiliation

Department of Orthopedic Surgery and Trauma, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

m.taha.mehanna@med.suez.edu.eg

City

-

Orcid

-

First Name

Noha

Last Name

Mesbah

MiddleName

M.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

nohe_mesbah@pharm.suez.edu.eg

City

-

Orcid

-

First Name

Dina

Last Name

Abo-Elmatty

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Email

dina_abouelmouti@pharm.suez.edu.eg

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

47567

Issue Date

2024-05-01

Receive Date

2023-12-22

Publish Date

2024-05-01

Page Start

21

Page End

36

Print ISSN

2536-9857

Online ISSN

2535-2091

Article File

RPBS_Volume 8_Issue 1_Pages 21-36.pdf

PDF . 867.8kB

Link

https://rpbs.journals.ekb.eg/article_353888.html

Detail API

https://rpbs.journals.ekb.eg/service?article_code=353888

Order

353,888

Type

Original Article

Type Code

532

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Genetic and Epigenetic Insights into Osteoarthritis Pathogenesis; Spotlighting STAT3 and miR-452-3p as Illuminating Examples

Details

Type

Article

Created At

23 Dec 2024