321731

Role of Wnt/β-Catenin pathway in the Pathophysiology of Alzheimer’s Disease

Article

Last updated: 03 Jan 2025

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Abstract

Alzheimer's disease (AD) is a progressive neurological disorder mainly affecting the elderly. AD demonstrates a gradual deterioration in cognitive functions. Alzheimer's disease is marked by the existence of intracellular flame-shaped neurofibrillary tangles (NFTs) and extracellular plaques of β-amyloid (Aβ) deposition known as amyloid plaques. Degeneration of synapses correlates to cognitive decline in patients with AD along with two hallmarks of AD. Inhibition in the Wnt signaling pathway contributes to AD pathogenesis by triggering synaptic dysfunction and neuronal degeneration. Suppression of Wnt/β-catenin signaling induced by an increase of GSK-3β activation and degradation of β-catenin. Furthermore, it was suggested that Aβ initiates the deregulation of Wnt signaling with a consequent inhibition of synapses. The binding of Wnt protein to Fzd/LRP causes inhibition of GSK3β and consequent activation of Wnt/β-catenin signalling. The activation of Wnt/β-catenin signaling prevents Aβ deposition and tau hyperphosphorylation in the brain. Therefore, restoring Wnt/β-catenin signaling could be a therapeutic opportunity to prevent the development of AD deterioration.

DOI

10.21608/rpbs.2023.234253.1241

Keywords

Alzheimer's disease, β-amyloid (Aβ), β-catenin, Wnt signaling, synapse dysfunction

Authors

First Name

Mangreed

Last Name

Atef

MiddleName

Mohammed

Affiliation

Suez Canal University Teaching Hospitals, Ismailia, Egypt.

Email

mangreed_atef@hotmail.com

City

Ismailia

Orcid

-

First Name

Yasser

Last Name

Moustafa

MiddleName

M

Affiliation

Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo, Egypt.

Email

yasser_mostafa@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0001-5394-5559

First Name

Amal

Last Name

Ahmed

MiddleName

A M

Affiliation

Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Email

amal_ahmed@vet.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Norhan

Last Name

El-Sayed

MiddleName

Mohamed

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt

Email

norhan.ms@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0002-0432-3152

Volume

7

Article Issue

3

Related Issue

38939

Issue Date

2023-01-01

Receive Date

2023-09-05

Publish Date

2023-01-01

Page Start

156

Page End

164

Print ISSN

2536-9857

Online ISSN

2535-2091

Link

https://rpbs.journals.ekb.eg/article_321731.html

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https://rpbs.journals.ekb.eg/service?article_code=321731

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321,731

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Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Role of Wnt/β-Catenin pathway in the Pathophysiology of Alzheimer’s Disease

Details

Type

Article

Created At

23 Dec 2024