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296872

Nanoemulsion formulation for enhancing the aqueous solubility and systemic bioavailability of poorly soluble drugs.

Article

Last updated: 03 Jan 2025

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Abstract

Nano emulsions are systems for delivering drugs of poor water-solubility with extensive first-pass metabolism and improving their bioavailability. Different techniques develop nano emulsions. Low-energy methods are more effective and do not require expensive equipment, so they should be used instead of high-energy methods. However, high-energy procedures are better for food-substance emulsions as they require a lower surfactant concentration than low-energy approaches. Particularly for low-energy processes, the formulation of nano emulsions involves overlapping techniques.
Due to their small particle sizes, nano emulsions are effective in emulsifying active lipophilic compounds and have a variety of uses, which is a promising advantage over conventional emulsions. These systems appear optically clear and have better stability as a result.
Also, the diffusion of bioactive substances into the intradermal layers is improved by nano emulsion food component systems, which is crucial in the development of herbal cosmetics.
The nano emulsion technology has demonstrated the ability to effectively distribute lipophilic compounds via various administration routes. Nano emulsion systems are beneficial for aesthetic applications due to their transparency, low viscosity, and nano-sized droplets. Antibiotics, anticancer agents, disinfectants, and antiseptics can all be given utilising nano emulsion systems due to their adaptable physiochemical properties, which also enhance the bioactivity of the encapsulated components.

DOI

10.21608/rpbs.2023.203561.1221

Keywords

drug delivery systems, Nano emulsion, high-energy approach, low-energy method

Authors

First Name

Shadeed

Last Name

Gad

MiddleName

-

Affiliation

Faculty of Pharmacy - Suez Canal University

Email

shaded_abdelrahman@pharm.suez.edu.eg

City

Ismailia

Orcid

0000-0001-7714-2267

First Name

Rasha

Last Name

Zidan

MiddleName

-

Affiliation

Dept. of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522,

Email

ph.rasha.zidan@gmail.com

City

-

Orcid

-

Volume

7

Article Issue

3

Related Issue

38939

Issue Date

2023-01-01

Receive Date

2023-04-01

Publish Date

2023-01-01

Page Start

103

Page End

108

Print ISSN

2536-9857

Online ISSN

2535-2091

Link

https://rpbs.journals.ekb.eg/article_296872.html

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https://rpbs.journals.ekb.eg/service?article_code=296872

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296,872

Type

Mini-reviews

Type Code

534

Publication Type

Journal

Publication Title

Records of Pharmaceutical and Biomedical Sciences

Publication Link

https://rpbs.journals.ekb.eg/

MainTitle

Nanoemulsion formulation for enhancing the aqueous solubility and systemic bioavailability of poorly soluble drugs.

Details

Type

Article

Created At

23 Dec 2024