The present study was carried out to demonstrate the microbiological quality of nonsterile pharmaceutical drops produced by Egyptian companies. For this purpose, commercially available non-sterile pharmaceutical drops products were obtained from different Egyptian manufacturers, which are currently purchased sporadically from various retail pharmacies in Egypt. They were unopened before testing. The non-sterile pharmaceutical drops were of Multivitamin and General Tonic Drops. Quantitively, there was no viable bacterial growth in 291(80.83%) of the tested samples and 315(87.50%) of the tested samples were free from fungi. Qualitative, non-sterile pharmaceutical drops were including Staphylococcus epidermidis, Staphylococcus aureus, Bacillus subtilis, Micrococcus species, Pneumonia, Pseudomonas aeruginosa, Salmonella species, Aspergillus niger, Saccharomyces species, Penicillium species, and Aspergillus flavus. Several measures, including equipment automation, monitoring programs and post-marketing surveillance are required to reduce the level of microbial contamination. Bacillus subtilis, Micrococcus species, Pneumonia, Pseudomonas aeruginosa, Salmonella species, Aspergillus niger, Saccharomyces species, Penicillium species, and Aspergillus flavus. Several measures, including equipment automation, monitoring programs and post-marketing surveillance are required to reduce the level of microbial contamination.