Herbal medicine is considered a natural source of a variety of beneficial active constituents. Since ancient times, herbal medicines have been used to cure different types of diseases. The World Health Organization (WHO) reports that the usage of herbal medicines has surpassed that of conventional pharmaceuticals by a factor of two to three worldwide due to it showed a remarkable safety profile when compared to conventional medicine. The use of herbal plants for primary healthcare is expanding tremendously. This isn't just because they are less expensive, but also because they are more widely accepted culturally, work better with the human body, and have less adverse effects. The process of extracting medicinal plants involves separating active plant extracts or secondary metabolites using the proper solvent and various extraction techniques. The Labiatae (Lamiaceae) family is one of the largest and most distinctive families of flowering plants, with about 220 genera and nearly 4000 species worldwide. Genius Marrubium consists of 97 flowering plants belonging to the Labiatae family that are native to the temperate regions of Europe, North Africa and Asia. Some other species grow in North and South America. This genus also contains a wide range of compounds including terpenes, oils, iridoids, sterols, glycosides, saponins, phenolic compounds and flavonoids. The species of this genus are characterized through having potential therapeutic activities as antispasmodic, hypolipidemic, hypotensive, hypoglycemic, anti-inflammatory and analgesic properties. This chemical review shows genus Marrubium plants extract contains different classes of bioactive chemical classes as terpenes, flavonoids, essential oil and sterols.