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356044

The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Biochemistry

Abstract

Background: Survivin is one of the most crucial apoptosis inhibitory genes, playing a basic role in hepatocellular carcinoma (HCC) development and progression. The current study aims at investigating the relationship of survivin polymorphism with the risk of HCC in Hepatitis C virus-infected Egyptian population.
Methods: the study was conducted on 120 Egyptian individuals divided into: healthy controls, fibrotic patients, cirrhotic patients and HCC patients (30 subjects/group). History and risk factors were collected and recorded for all cases. Polymorphism of the survivin gene, including one locus (rs9904341) was chosen for genotyping using (PCR-RFLP) technique.
Results: No statistically significant difference was detected in the genotype or allele distribution of HCC subjects in respect to the controls (P>0.05). On the other hand, a significant difference could be detected in genotype or allele distribution in fibrosis and cirrhosis HCV patient groups compared to healthy controls (P<0.05). A significant difference in genotype or allele distribution was detected in HCC group compared to cirrhosis group (P<0.05). No statistically significant difference was found in genotype or allele distribution of fibrosis cases relative to the controls.
Conclusion: No relationship between Survivin gene (-31G/C) polymorphism rs9904341 and the risk of HCC could be found in HCV-infected Egyptian population. However, a positive correlation could be detected between Survivin gene polymorphism and the risk of cirrhosis in the same population. The study also identified a relationship between survivin gene polymorphism in cirrhosis relative to fibrosis as well as between survivin gene (–31G/C) polymorphism rs9904341 in HCC relative to cirrhosis.

DOI

10.21608/jabps.2024.278357.1217

Keywords

survivin, -31G/C polymorphism, Hepatocellular carcinoma, fibrosis

Authors

First Name

Heba

Last Name

Eltahir

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

htahir@taibahu.edu.sa

City

-

Orcid

-

First Name

Sherif

Last Name

Maher

MiddleName

Ali

Affiliation

Department of Biochemistry, Faculty of pharmacy, New valley University, New Valley, El-kharga city 71511, Egypt

Email

sherif.ali87@pha.nvu.edu.eg

City

-

Orcid

-

First Name

Mahmoud

Last Name

Elrihany

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of pharmacy, Deraya University, New Minia city 61111, Egypt

Email

mahmoud.elrehany@deraya.edu.eg

City

-

Orcid

-

First Name

Hala

Last Name

Mohamed

MiddleName

Ibrahim

Affiliation

Department of hepatology and gastroenterology, Faculty of medicine, Minia University, Minia city 61519, Egypt

Email

halaibrahem@mu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

wahid

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of pharmacy, Alexindria University, Egypt

Email

ahmedwahid2009@yahoo.com

City

-

Orcid

-

First Name

Amer

Last Name

Alamri

MiddleName

A

Affiliation

Medical center Taibah University, Medina, Kingdom of Saudi Arabia

Email

ameropharm@hotmail.com

City

-

Orcid

-

First Name

Sultan

Last Name

Al thagfan

MiddleName

-

Affiliation

Department of clinical and hospital pharmacy, College of Pharmacy, Taibah University, Medina, Kingdom of Saudi Arabia

Email

sthqfan@taibahu.edu.sa

City

-

Orcid

-

First Name

Meky

Last Name

Abouzied

MiddleName

M

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.

Email

mabouzied@taibahu.edu.sa

City

Almadinah Almonawara

Orcid

-

First Name

Abdel-Gawad

Last Name

Shalkami

MiddleName

S

Affiliation

Clinical Pharmacy program, Al-Rayan Colleges, Medina, Kingdom of Saudi Arabia

Email

as.abdulgawad@amc.edu.sa

City

-

Orcid

-

First Name

Michael

Last Name

Fawzy

MiddleName

A

Affiliation

Department of faculty of Pharmacy, Minia University, Minia, Egypt

Email

michaelfawzy777@yahoo.com

City

-

Orcid

-

Volume

7

Article Issue

3

Related Issue

49074

Issue Date

2024-07-01

Receive Date

2024-03-20

Publish Date

2024-07-01

Page Start

103

Page End

108

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 7_Issue 3_Pages 103-108.pdf

PDF . 423.1kB

Link

https://jabps.journals.ekb.eg/article_356044.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=356044

Order

3

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

The association between the survivin gene -31G/C polymorphism and risk of hepatocellular carcinoma in Egyptian population.

Details

Type

Article

Created At

23 Dec 2024