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331627

Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Biochemistry

Abstract

Hepatocellular carcinoma (HCC) is a brutally aggressive cancer that puts a tremendous amount of strain on both the medical systems and the drug regulatory organizations as well. It is believed that a crucial stage in the development of HCC is the epithelial-mesenchymal transition (EMT), which increases hepatocyte malignancy and is linked to invasion and metastasis. Resveratrol (RES) has been shown to reverse EMT in a number of cancer types. In order to further understand how RES influences EMT in HCC, we have chosen to concentrate on studying and summarizing the serine/threonine kinase (Akt)/glycogen synthesis kinase 3-beta (GSK3β)/Snail signaling pathway as one of the central pathways involved in activating EMT and tumorigenesis in this review.

DOI

10.21608/jabps.2023.233421.1201

Keywords

Hepatocellular carcinoma, epithelial-mesenchymal transition, Resveratrol, Akt/GSK3β/Snail pathway

Authors

First Name

Asmaa

Last Name

Bayoumi

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Email

asmaa_bayoumi@mu.edu.eg

City

-

Orcid

0000-0001-6757

First Name

Esraa

Last Name

Khalifa

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Email

esramontaser88@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Sayed-Ahmed

MiddleName

M.

Affiliation

Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo 11796, Egypt.

Email

sayed.ahmed@nci.cu.edu.eg

City

-

Orcid

0000-0002-2179-8002

First Name

Marwa

Last Name

Sharaky

MiddleName

-

Affiliation

Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo 11796, Egypt.

Email

marwa.sharaky@nci.cu.edu.eg

City

-

Orcid

0000-0002-7894-3514

First Name

Maiiada

Last Name

Nazmy

MiddleName

H.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Email

maiiada_nazmy@mu.edu.eg

City

Minia

Orcid

-

Volume

7

Article Issue

1

Related Issue

45148

Issue Date

2024-01-01

Receive Date

2023-09-06

Publish Date

2024-01-01

Page Start

37

Page End

40

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 7_Issue 1_Pages 37-40.pdf

PDF . 380.0kB

Link

https://jabps.journals.ekb.eg/article_331627.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=331627

Order

4

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Resveratrol inhibits epithelial-mesenchymal transition in hepatocellular carcinoma

Details

Type

Article

Created At

23 Dec 2024