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331624

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

In recent years, the use of quinazoline and its derivatives as structural scaffolds has shown significant promise in drug design. These compounds have shown significant biological efficacy in the treatment of a variety of diseases, including cancer. Quinazoline has shown a significant reduction in adverse effects and improved treatment effectiveness, making it a very attractive candidate for further investigation and advancement in therapeutic interventions. This review provides a focus on the use of small-molecule targeted therapy. The discussion briefly introduces the epidermal growth factor receptor tyrosine kinase (EGFR TK), its mutations, and the development of innovative molecules in this domain. Furthermore, the current review digs into the concept of multi-targeted anticancer agents, particularly on quinazoline-based compounds that can obstruct several targets. Notably, these targets include EGFR/VEGFR dual inhibitors, EGFR/HDAC dual inhibitors, and a variety of other EGFR-related targets.

DOI

10.21608/jabps.2023.234736.1203

Keywords

Quinazoline, Molecular Targeted Therapy, EGFR TKIs, EGFR/VEGFR dual inhibitors, EGFR/HDAC dual inhibitors

Authors

First Name

Mostafa

Last Name

Mansour

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University in Beni-Suef (NUB), Beni-Suef 62513, Egypt.

Email

mostafa.mansour@nub.edu.eg

City

Beni Suef

Orcid

0000-0002-0179-8398

First Name

Samar

Last Name

Abbas

MiddleName

H

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

drsamar77@hotmail.com

City

Minia

Orcid

0000-0002-9586-2644

First Name

Asma

Last Name

AboulMagd

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Nahda University, Beni Suef 62513, Egypt.

Email

asmaa.aboulmaged@nub.edu.eg

City

-

Orcid

0000-0003-4243-9401

First Name

Hamdy

Last Name

Abdel-Rahman

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

Email

hamdym@aun.edu.eg

City

-

Orcid

0000-0003-1355-8380

First Name

Mohamed

Last Name

Osman

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

Email

abulnil@hotmail.com

City

Minia

Orcid

-

Volume

7

Article Issue

1

Related Issue

45148

Issue Date

2024-01-01

Receive Date

2023-09-06

Publish Date

2024-01-01

Page Start

1

Page End

17

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 7_Issue 1_Pages 1-17.pdf

PDF . 1.2MB

Link

https://jabps.journals.ekb.eg/article_331624.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=331624

Order

1

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

The significance of quinazoline derivatives as potential multi-target anti-cancer agents: review article

Details

Type

Article

Created At

23 Dec 2024