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319414

Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Microbiology

Abstract

Genetic variables have a notable and polygenic impact on the incidence and development of hepatic fibrosis and cirrhosis in individuals with chronic hepatitis C (CHC). Genetic polymorphisms in interferon-λ3-interferon- λ4 (INFL3-INFL4) region, rs12979860 and its highly linked disequilibrium polymorphisms (rs368234815 and rs4803217) are linked to liver inflammation and fibrosis progression in CHC individuals from different ethnic groups. For Egyptian patients, no data available about the degree of linkage disequilibrium between these variants and their effect on liver fibrosis. In this study, 99 healthy controls and 176 CHC patients were genotyped for 3 variants in (INFL3-INFL4) region rs12979860, rs4803217, and rs368234815. We found that these variants are highly linked disequilibrium in Egyptian CHC cohort. Moreover, we found that the major alleles of these 3 polymorphisms (rs12979860, rs4803217, and rs368234815) significantly increase the risk of liver fibrosis (P = 0.015, 0.026, and 0.007 respectively). Additionally, these variants were linked to stage of hepatic fibrosis. This report shows that the 3 linked disequilibrium variants in INFL3-INFL4 region may be valuable foretellers of liver fibrosis and cirrhosis in CHC Egyptian patients.

DOI

10.21608/jabps.2023.233765.1199

Keywords

INFL3-INFL4 variants, Liver fibrosis, Cirrhosis, CHC, Egyptian patients

Authors

First Name

Khalid

Last Name

Thabit

MiddleName

-

Affiliation

Department of biochemistry, faculty of Pharmacy, Minia University, Minia, Egypt

Email

khaled_thabet@minia.edu.eg

City

-

Orcid

-

First Name

Amany

Last Name

Bkeet

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

amany_bkeet@mu.edu.eg

City

-

Orcid

-

First Name

Elham

Last Name

Abdelhalem

MiddleName

-

Affiliation

Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

elham.abdelhalem@med.aun.edu.eg

City

-

Orcid

-

First Name

Abeer

Last Name

Sharaf

MiddleName

-

Affiliation

Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

sharafabeer@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Eltahir

MiddleName

-

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Almunawwarah, Kingdom of Saudi Arabia

Email

htahir@taibahu.edu.sa

City

-

Orcid

-

First Name

Meky

Last Name

Abouzied

MiddleName

M

Affiliation

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.

Email

mabouzied@taibahu.edu.sa

City

Almadinah Almonawara

Orcid

-

First Name

Abo Bakr

Last Name

Ahmed

MiddleName

F

Affiliation

Microbiology and Immunology department, Faculty of Pharmacy, Minia University, Minia, Egypt

Email

abobakr_fathe@mu.edu.eg

City

-

Orcid

0000-0003-4430-6098

Volume

6

Article Issue

4

Related Issue

43728

Issue Date

2023-10-01

Receive Date

2023-09-03

Publish Date

2023-10-01

Page Start

228

Page End

233

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 6_Issue 4_Pages 228-233.pdf

PDF . 498.7kB

Link

https://jabps.journals.ekb.eg/article_319414.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=319414

Order

7

Type

Original Article

Type Code

522

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Single nucleotide polymorphisms in INFL3-INFL4 region are associated with fibrosis and cirrhosis in Egyptian patients with chronic hepatitis C

Details

Type

Article

Created At

23 Dec 2024