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319054

Derivatives contain dimethylaminopyridine as SIRT2 inhibitors: A mini review

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

The development of new compounds inhibiting SIRT2, a protein that regulates various biological processes, has attracted significant attention in recent years. This study reported dimethylaminopyridine (DMAP) synthesis and evaluation as a new scaffold for SIRT2 inhibition. DMAP derivatives were designed and synthesized using a combination of computational modeling and synthetic chemistry approaches. A high-throughput screening assay was used to evaluate the ability of compounds to inhibit SIRT2. The most potent compounds were identified and further characterized using cellular and enzymatic assays. This review suggests that DMAP could be a promising scaffold for developing novel SIRT2 inhibitors with potential anticancer activity.

DOI

10.21608/jabps.2023.219233.1191

Keywords

Dimethyl aminopyridine, HDACs, SiRT2 inhibitors

Authors

First Name

Mostafa

Last Name

Badran

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, South Valley University, Qena, 83523, Egypt

Email

mostbadran@svu.edu.eg

City

-

Orcid

-

First Name

Samar

Last Name

Abbas

MiddleName

H

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 61519-Minia, Egypt

Email

drsamar77@hotmail.com

City

Minia

Orcid

0000-0002-9586-2644

First Name

Mikako

Last Name

Fujita

MiddleName

-

Affiliation

Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto, 862-0973, Japan

Email

mfujita@kumamoto-u.ac.jp

City

-

Orcid

-

First Name

Mohamed

Last Name

Osman

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

Email

abulnil@hotmail.com

City

Minia

Orcid

-

Volume

6

Article Issue

4

Related Issue

43728

Issue Date

2023-10-01

Receive Date

2023-06-21

Publish Date

2023-10-01

Page Start

166

Page End

173

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 6_Issue 4_Pages 166-173.pdf

PDF . 1.9MB

Link

https://jabps.journals.ekb.eg/article_319054.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=319054

Order

2

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Derivatives contain dimethylaminopyridine as SIRT2 inhibitors: A mini review

Details

Type

Article

Created At

23 Dec 2024