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Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Analytical and Medicinal Chemistry

Abstract

Dihydropyrimidines (DHPMs) are a class of nitrogen-containing heterocycles that have attracted considerable interest due to their great significance in organic and medicinal chemistry. In recent years, many biologically active molecules featuring DHPM moiety have been synthesized and biologically evaluated, some of which have served as potential leads for critical unmet pathological conditions such as the antimitotic Monastrol and the antiviral GLS4, which entered clinical trials a few years ago. This review discusses briefly the recent advances in DHPM-based bioactive compounds, their biological activities, and their mechanisms of action, which could provide references for future developments of more potent and selective leads.

DOI

10.21608/jabps.2023.198467.1183

Keywords

dihydropyrimidine, Biginelli, Anticancer, Antibacterial, Anti-Alzheimer's

Authors

First Name

Ali

Last Name

Elshamsy

MiddleName

M.

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt

Email

alielshamsy123@gmail.com

City

-

Orcid

-

First Name

Taha

Last Name

Ali

MiddleName

F. S.

Affiliation

Department of Medicinal chemistry, Faculty of pharmacy, Minia university, Minia, Egypt

Email

taha.ali@mu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Osman

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Minia University.

Email

abulnil@hotmail.com

City

Minia

Orcid

-

First Name

Nawal

Last Name

El-Koussi

MiddleName

A.

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt; Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

nawalelkoussi@yahoo.com

City

-

Orcid

-

Volume

6

Article Issue

3

Related Issue

42142

Issue Date

2023-07-01

Receive Date

2023-03-07

Publish Date

2023-07-01

Page Start

114

Page End

123

Print ISSN

2535-1869

Online ISSN

2535-2040

Article File

JABPS_Volume 6_Issue 3_Pages 114-123.pdf

PDF . 913.7kB

Link

https://jabps.journals.ekb.eg/article_303620.html

Detail API

https://jabps.journals.ekb.eg/service?article_code=303620

Order

1

Type

Review Articles

Type Code

523

Publication Type

Journal

Publication Title

Journal of advanced Biomedical and Pharmaceutical Sciences

Publication Link

https://jabps.journals.ekb.eg/

MainTitle

Recent progress in biological activities of dihydropyrimidine derivatives: An updated mini-review

Details

Type

Article

Created At

23 Dec 2024