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360414

COMPARATIVE STUDY AMONG THREE MANIPULATING RATIO SPECTRA METHODS FOR THE DETERMINATION OF MOLNUPIRAVIR IN PRESENCE OF ITS ACID-INDUCED DEGRADATION PRODUCT

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical analytical chemistry and instrumental analysis

Abstract

The main purpose of this work is to establish three simple, sensitive, accurate and precise spectrophotometric methods manipulating ratio spectra for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product. Ratio derivative, ratio difference and mean centering of ratio spectra are simple, rapid and selective methods using manipulation of ratio spectra for the determination of components having overlapping spectra. The suggested methods were validated in compliance with the ICH guidelines and were successfully applied for determination of molnupiravir in bulk powder and in pharmaceutical preparation in the presence of its acid-induced degradation product.


DOI

10.21608/ajps.2024.360414

Keywords

UV–VIS, Spectrophotometry, Ratio derivative, Ratio difference, Mean centering, Acid-induced degradation product, Molnuprivir

Authors

First Name

Mohamed

Last Name

Nassar

MiddleName

Wafaa

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt

Email

mw-nassar@yahoo.com

City

-

Orcid

-

First Name

Ashraf

Last Name

Abdelfatah

MiddleName

-

Affiliation

1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Madkor

MiddleName

W

Affiliation

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy (Boys), Al-Azhar University,11751, Nasr City, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdelaziz

MiddleName

A

Affiliation

Armed Forces Collage Of Medicine Hospital (AFCMH),Military Medical Academy (MMA) Cairo, Egypt

Email

mohamed_othman@azhar.edu.eg

City

-

Orcid

-

Volume

69

Article Issue

1

Related Issue

48482

Issue Date

2024-03-01

Receive Date

2024-06-12

Publish Date

2024-03-01

Page Start

130

Page End

151

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 69_Issue 1_Pages 130-151.pdf

PDF . 1.9MB

Link

https://ajps.journals.ekb.eg/article_360414.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=360414

Order

360,414

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

COMPARATIVE STUDY AMONG THREE MANIPULATING RATIO SPECTRA METHODS FOR THE DETERMINATION OF MOLNUPIRAVIR IN PRESENCE OF ITS ACID-INDUCED DEGRADATION PRODUCT

Details

Type

Article

Created At

23 Dec 2024