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360361

PYRAZOLOPYRIMIDINES AS ANTICANCER AGENTS; SYNTHESES AND MODE OF ACTION (REVIEW ARTICLE)

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Medicinal chemistry and drug design

Abstract

Pyrazolopyrimidines are composed of a pyrazole ring fused with pyrimidine moiety, unlike the imidazole moiety in purines; they are initially reported as adenosine receptor antagonists. Different methods of synthesis of substituted pyrazolo[3,4-d]pyrimidines and pyrazolo[1,5-a]pyrimidines have been reported with a survey of their biological activities especially anti-cancer activity. During the last two decades, pyrazolopyrimidines have gained great attention as biologically active compounds; they are reported to have anti-cancer activity, anti-microbial, anti-inflammatory, anti-hyperuricemia, anti-viral and anti-hypertensive activities. Researchers paid great attention to pyrazolopyrimidines due to their high anti-cancer activity, so they tried to prepare new derivatives and examine their anti-cancer activity. In this review we are going to focus on the different methods used for the synthesis of pyrazolopyrimidines, their anticancer activities as well as their reported mode of action.

DOI

10.21608/ajps.2024.360361

Keywords

pyrazolopyrimidine, Anti-cancer, Synthesis, Mode of action

Authors

First Name

Wafaa

Last Name

Zaghary

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Tamer

Last Name

Nasr

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.

Email

tamerhefni@yahoo.com

City

-

Orcid

-

First Name

Rania

Last Name

Abd El-Hameed

MiddleName

-

Affiliation

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.

Email

zeiadomar@yahoo.com

City

-

Orcid

-

First Name

Tamer

Last Name

Sakr

MiddleName

M

Affiliation

Radioactive Isotopes and Generator Department, Hot Labs Center, Egyptian Atomic Energy Authority, 13759, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Dina

Last Name

Osman

MiddleName

Adel

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

El-Adl

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Email

khaled.eladl@hu.edu.eg

City

-

Orcid

-

Volume

69

Article Issue

1

Related Issue

48482

Issue Date

2024-03-01

Receive Date

2024-06-12

Publish Date

2024-03-01

Page Start

62

Page End

107

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 69_Issue 1_Pages 62-107.pdf

PDF . 2.4MB

Link

https://ajps.journals.ekb.eg/article_360361.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=360361

Order

360,361

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

PYRAZOLOPYRIMIDINES AS ANTICANCER AGENTS; SYNTHESES AND MODE OF ACTION (REVIEW ARTICLE)

Details

Type

Article

Created At

23 Dec 2024