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360355

AN INSIGHT ON MEDICINAL ATTRIBUTES OF PHTHALAZINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER PROPERTIES AS VEGFR-2 INHIBITORS

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Medicinal chemistry and drug design

Abstract

The antitumor properties of synthetic heterocyclic compounds are among the most powerful properties that can be made use in medicinal chemistry. More specifically, their significant cytotoxic effects against many types of human tumor cells, as well as their roles as various kinase inhibitors. In recent years, Phthalazine derivatives, have frequently attracted the interest of medicinal chemistry researchers due to their promising anticancer properties. The present study is a review of the latest advances in Phthalazine derivative-related research, with a focus on their anticancer activities as VEGFR-2 inhibitors.

DOI

10.21608/ajps.2024.360355

Keywords

Anticancer, phthalazine, VEGFR-2 inhibitors, Kinase, Angiogenesis

Authors

First Name

Mohammed

Last Name

Dahab

MiddleName

A

Affiliation

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Email

mohammeddahab@azhar.edu.eg

City

-

Orcid

-

First Name

Hatem

Last Name

Bayoumi

MiddleName

B

Affiliation

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Email

-

City

-

Orcid

-

First Name

Fathalla

Last Name

Khedr

MiddleName

-

Affiliation

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ibrahim

MiddleName

K

Affiliation

Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt

Email

-

City

-

Orcid

-

Volume

69

Article Issue

1

Related Issue

48482

Issue Date

2024-03-01

Receive Date

2024-06-12

Publish Date

2024-03-01

Page Start

25

Page End

37

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 69_Issue 1_Pages 25-37.pdf

PDF . 835.4kB

Link

https://ajps.journals.ekb.eg/article_360355.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=360355

Order

360,355

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

AN INSIGHT ON MEDICINAL ATTRIBUTES OF PHTHALAZINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER PROPERTIES AS VEGFR-2 INHIBITORS

Details

Type

Article

Created At

23 Dec 2024