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332170

VEGFER-2 INHIBITORS AND QUINAZOLINE-BASED ANTICANCER AGENTS

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Medicinal chemistry and drug design

Abstract

Inhibitors of vascular endothelial growth factor receptor -2 (VEGFR-2) are crucial biological targets for the development of novel anticancer medications. Quinazoline also plays an important role as one of the building elements of numerous anticancer drugs. Thus, a review of the literature on VEGFR-2 inhibitors and Quinazoline-based anticancer medicines has been completed. We introduced VEGFR-2 inhibitors now undergoing clinical evaluation, such as Gefitinib, Erlotinib, Vandetanib, Afatinib, Lenvatinib, Cabozantinib, Sorafenib and Regorafenib in our survey. Additionally, VEGFR-2 inhibitors that are under development were introduced.

DOI

10.21608/ajps.2023.332170

Keywords

Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors, Quinazoline, Anti-cancer agents

Authors

First Name

Helmy

Last Name

Sakr

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Email

helmysakr@azhar.edu.eg

City

-

Orcid

-

First Name

Islam

Last Name

Otify

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt

Email

-

City

-

Orcid

-

First Name

Rezk

Last Name

Ayyad

MiddleName

R

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Elwan

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt

Email

-

City

-

Orcid

-

Volume

68

Article Issue

2

Related Issue

44970

Issue Date

2023-09-01

Receive Date

2023-12-25

Publish Date

2023-09-01

Page Start

111

Page End

129

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 68_Issue 2_Pages 111-129.pdf

PDF . 592.3kB

Link

https://ajps.journals.ekb.eg/article_332170.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=332170

Order

332,170

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

VEGFER-2 INHIBITORS AND QUINAZOLINE-BASED ANTICANCER AGENTS

Details

Type

Article

Created At

23 Dec 2024