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332167

PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Medicinal chemistry and drug design

Abstract

Pyridine derivatives are a family of heterocyclic nitrogenous compounds possessing many of applications in the discovery of  anticancer drug. This synthetic category serve as the potent class of compounds in the treatment of  many types of tumors as breast cancer, myeloid leukemia, pancreatic cancer, liver cancer. In this review, the recent results of the published studies about pyridine derivatives were reported. In addition, the most promising candidates in each work was focused mentioning it anticancer activity compared to the reference molecules. This work may serve as a collection of promising candidates for further design and synthesis of  anti-cancer agents.

DOI

10.21608/ajps.2023.332167

Keywords

Pyridine derivative, Anti-cancer agents, Biological targets

Authors

First Name

Mohamed Ayman

Last Name

El-Zahabi

MiddleName

ALy

Affiliation

Al Mockhaim Al Daem street, Nasr 6thdistrict, Cairo Egypt

Email

malzahaby@azhar.edu.eg

City

Nasr

Orcid

0000-0003-4538-5840

First Name

Reda

Last Name

Yousef

MiddleName

G

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo11884, Egypt.

Email

-

City

-

Orcid

-

First Name

Ibrahim

Last Name

Eissa

MiddleName

H

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo11884, Egypt.

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Elwan

MiddleName

-

Affiliation

Department of Pharmaceutical Medicinal Chemistry & Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo11884, Egypt.

Email

-

City

-

Orcid

-

Volume

68

Article Issue

2

Related Issue

44970

Issue Date

2023-09-01

Receive Date

2023-12-25

Publish Date

2023-09-01

Page Start

64

Page End

81

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 68_Issue 2_Pages 64-81.pdf

PDF . 617.1kB

Link

https://ajps.journals.ekb.eg/article_332167.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=332167

Order

332,167

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

PYRIDINE DERIVATIVES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS

Details

Type

Article

Created At

23 Dec 2024