Sildenafil citrate (SILD) is a drug of choice used in the treatment of premature ejaculation disorders. Oral administration of Sildenafil was accompanied with several side effects including nausea, vomiting, diarrhoea and stomach cramps. Topical administration of sildenafil could avoid the side effects of oral or systemic administration of the drug. Therefore, the present study was undertaken to formulate and evaluate transdermal gel of Sildenafil citrate. Sildenafil hydrogels were prepared using different polymers such as HPMC, Pluronic F127, CMC Na and Na-alginate. The formulated gels were characterized by measuring different parameters such as pH, viscosity, spreadability and in vitro diffusion study. The results showed that all medicated hydrogels formula showed good consistency, spreadability and homogeneity. Especially, the gel containing HPMC and PEG 400 as permeation enhancer showed the best results compared to other gelling agents. The release mechanism of the drug from hydrogels was Higushi diffusion mechanism. As a conclusion, it was concluded that the modified SILD gel is an alternative therapy for the patients suffering from mild to moderate erectile dysfunction ( ED ) with premature ejaculation (PE) since this rout of administration avoid the risk of side effect accompanying the oral administration of drug.